Ontology highlight
ABSTRACT:
SUBMITTER: Tokatlian T
PROVIDER: S-EPMC6420719 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20181220 6427
In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. We compared the fates of two different heavily glycosylated HIV antigens, a gp120-derived mini-protein and a large, stabilized envelope trimer, in protein nanoparticle or "free" forms after primary immunization. Unlike monomeric antigens, nanoparticles were rapidly shuttled to the follicular dendritic cell (F ...[more]