Ontology highlight
ABSTRACT:
SUBMITTER: Kallappagoudar S
PROVIDER: S-EPMC3771349 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Proteomics 20130426 10-11
Many histone covalent modifications have been identified and shown to play key regulatory roles in eukaryotic transcription, DNA damage repair, and replication. In vitro experiments designed to understand the mechanistic role of individual modifications require the availability of substantial quantities of pure histones, homogeneously modified at specific residues. We have applied the amber stop codon/suppressor tRNA strategy to the production of histone H4 acetylated at lysine 16, a particularl ...[more]