Ontology highlight
ABSTRACT:
SUBMITTER: McConnell N
PROVIDER: S-EPMC6103208 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
ChemistrySelect 20171219 35
Benzimidazoles and quinoxalinones are present in the core of many pharmacologically relevant compounds. Several combinatorial methods have been developed to attach ring systems to both scaffolds for derivatization at select positions. Herein, we describe the development of novel constrained heterocyclic compounds attached to the N1 position of both benzimidazole and quinoxalinone scaffolds. Utilizing robust post-Ugi cyclization methods, including the Ugi-deprotection-cyclization (UDC) methodolog ...[more]