Ontology highlight
ABSTRACT:
SUBMITTER: Lyons PA
PROVIDER: S-EPMC3773907 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Lyons Paul A PA Rayner Tim F TF Trivedi Sapna S Holle Julia U JU Watts Richard A RA Jayne David R W DR Baslund Bo B Brenchley Paul P Bruchfeld Annette A Chaudhry Afzal N AN Cohen Tervaert Jan Willem JW Deloukas Panos P Feighery Conleth C Gross Wolfgang L WL Guillevin Loic L Gunnarsson Iva I Harper Lorraine L Hrušková Zdenka Z Little Mark A MA Martorana Davide D Neumann Thomas T Ohlsson Sophie S Padmanabhan Sandosh S Pusey Charles D CD Salama Alan D AD Sanders Jan-Stephan F JS Savage Caroline O CO Segelmark Mårten M Stegeman Coen A CA Tesař Vladimir V Vaglio Augusto A Wieczorek Stefan S Wilde Benjamin B Zwerina Jochen J Rees Andrew J AJ Clayton David G DG Smith Kenneth G C KG
The New England journal of medicine 20120701 3
<h4>Background</h4>Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.<h4>Methods</h4>A genomewide association study was performed in a discovery cohort of ...[more]