Ontology highlight
ABSTRACT:
SUBMITTER: Tesar V
PROVIDER: S-EPMC9307875 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Tesar Vladimir V Hruskova Zdenka Z
Frontiers in immunology 20220708
Efficacy of immunosuppressive treatment of Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is complicated by its toxicity. With the replacement of cyclophosphamide with rituximab, serious adverse events seem to be associated especially with high-dose corticosteroids. Activation of alternative complement pathway plays an important role in the pathogenesis of AAV. Avacopan (C5a receptor inhibitor) was demonstrated to have at least similar efficacy and better safety (in term ...[more]