Ontology highlight
ABSTRACT:
SUBMITTER: McWilliams TG
PROVIDER: S-EPMC4407286 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cell reports 20150305 9
The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their innervation. Here, we report that an autocrine signaling loop in developing mouse sympathetic neurons involving CD40L (TNFSF5) and CD40 (TNFRSF5) selectively enhances NGF-promoted axon g ...[more]