Ontology highlight
ABSTRACT:
SUBMITTER: Bretherick KL
PROVIDER: S-EPMC3775730 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bretherick Karla L KL Schuetz Johanna M JM Morton Lindsay M LM Purdue Mark P MP Conde Lucia L Gallagher Richard P RP Connors Joseph M JM Gascoyne Randy D RD Berry Brian R BR Armstrong Bruce B Kricker Anne A Vajdic Claire M CM Grulich Andrew A Hjalgrim Henrik H Smedby Karin E KE Skibola Christine F CF Rothman Nathaniel N Spinelli John J JJ Brooks-Wilson Angela R AR
PloS one 20130917 9
H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by chromosomal translocations. We previously reported that rs2509049, a common variant in the promoter of H2AFX, was associated with risk for NHL in the British Columbia population. Here we report results for 13 single nucleotide polymorphisms (SNPs) in 1 ...[more]