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Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.

ABSTRACT: Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.

SUBMITTER: Chen Y

PROVIDER: S-EPMC3998836 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.

Chen Yingtai Y Lan Qing Q Zheng Tongzhang T Zhao Nan N Holford Theodore R TR Lerro Catherine C Dai Min M Huang Huang H Liang Jiaxin J Ma Shuangge S Leaderer Brian B Boyle Peter P Chanock Stephen S Rothman Nathaniel N Zhang Yawei Y

Leukemia research 20130612 9

Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs650369 ...[more]

PMID: 23768868

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