Ontology highlight
ABSTRACT:
SUBMITTER: Fabris S
PROVIDER: S-EPMC3775884 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Fabris Sonia S Bollati Valentina V Agnelli Luca L Morabito Fortunato F Motta Valeria V Cutrona Giovanna G Matis Serena S Grazia Recchia Anna A Gigliotti Vincenzo V Gentile Massimo M Deliliers Giorgio Lambertenghi GL Bertazzi Pier Alberto PA Ferrarini Manlio M Neri Antonino A Baccarelli Andrea A
Epigenetics 20110201 2
Global DNA hypomethylation affecting repeat sequences has been reported in different cancer types. Herein, we investigated the methylation levels of repetitive DNA elements in chronic lymphocytic leukemia (CLL), their correlation with the major cytogenetic and molecular features, and clinical relevance in predicting therapy-free survival (TFS). A quantitative bisulfite-PCR Pyrosequencing method was used to evaluate methylation of Alu, long interspersed nuclear elements-1 (LINE-1) and satellite-α ...[more]