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A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.

ABSTRACT: Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones.

SUBMITTER: Castaneda L

PROVIDER: S-EPMC3776223 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.

Castañeda Lourdes L Wright Zoë V F ZV Marculescu Cristina C Tran Trang M TM Chudasama Vijay V Maruani Antoine A Hull Elizabeth A EA Nunes João P M JP Fitzmaurice Richard J RJ Smith Mark E B ME Jones Lyn H LH Caddick Stephen S Baker James R JR

Tetrahedron letters 20130701 27

Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones. ...[more]

PMID: 24058217

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