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Synthesis of functionalised ?-keto amides by aminoacylation/domino fragmentation of ?-enamino amides.

ABSTRACT: Ethylenediamine-derived ?-enamino amides are used as equivalents of amide enolate synthons in C-acylation reactions with N-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised ?-keto amides, bearing a protected amino group in their side chain.

SUBMITTER: Yanev P

PROVIDER: S-EPMC6204755 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides.

Yanev Pavel P Angelov Plamen P

Beilstein journal of organic chemistry 20181010

Ethylenediamine-derived β-enamino amides are used as equivalents of amide enolate synthons in <i>C</i>-acylation reactions with <i>N</i>-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised β-keto amides, bearing a protected amino group in their side chain. ...[more]

PMID: 30410622

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