Ontology highlight
ABSTRACT:
SUBMITTER: McClure RA
PROVIDER: S-EPMC3778261 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
McClure Richard A RA Chumbley Chad W CW Reyzer Michelle L ML Wilson Kevin K Caprioli Richard M RM Gore John C JC Pham Wellington W
NeuroImage. Clinical 20130430
The identification of amyloid-binding compounds is a crucial step in the development of imaging probes and therapeutics for the detection and cure of Alzheimer's disease. Unfortunately, the process typically lags during the translation from in vitro to in vivo studies due to the impenetrable nature of the blood brain barrier (BBB). Here, we integrate fluorescence assay with MALDI imaging mass spectrometry to screen known compounds and repurpose their properties to enable the second function of b ...[more]