Ontology highlight
ABSTRACT:
SUBMITTER: Smillie KJ
PROVIDER: S-EPMC3778765 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intens ...[more]