Ontology highlight
ABSTRACT:
SUBMITTER: Pattani A
PROVIDER: S-EPMC3778941 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Pattani Aditya A McKay Paul F PF Garland Martin J MJ Curran Rhonda M RM Migalska Katarzyna K Cassidy Corona M CM Malcolm R Karl RK Shattock Robin J RJ McCarthy Helen O HO Donnelly Ryan F RF
Journal of controlled release : official journal of the Controlled Release Society 20120807 3
Dissolving polymeric microneedle arrays formulated to contain recombinant CN54 HIVgp140 and the TLR4 agonist adjuvant MPLA were assessed for their ability to elicit antigen-specific immunity. Using this novel microneedle system we successfully primed antigen-specific responses that were further boosted by an intranasal mucosal inoculation to elicit significant antigen-specific immunity. This prime-boost modality generated similar serum and mucosal gp140-specific IgG levels to the adjuvanted and ...[more]