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Molecular pathogenesis of hepatic adenomas and its implications for surgical management.

ABSTRACT:

Introduction

Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration.

Discussion

The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease.

SUBMITTER: Liau SS

PROVIDER: S-EPMC3782654 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Molecular pathogenesis of hepatic adenomas and its implications for surgical management.

Liau Siong-Seng SS Qureshi M Saeed MS Praseedom Raaj R Huguet Emmanuel E

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20130709 10

<h4>Introduction</h4>Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration.<h4>Discussion</h4>The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology under ...[more]

PMID: 23835731

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