Ontology highlight
ABSTRACT:
SUBMITTER: Leoni V
PROVIDER: S-EPMC4741489 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Leoni Valerio V Gatta Valentina V Gatta Valentina V Palladini Arianna A Nicoletti Giordano G Ranieri Dario D Dall'Ora Massimiliano M Grosso Valentina V Rossi Martina M Alviano Francesco F Bonsi Laura L Nanni Patrizia P Lollini Pier-Luigi PL Campadelli-Fiume Gabriella G
Oncotarget 20151001 33
Fully retargeted oncolytic herpes simplex viruses (o-HSVs) gain cancer-specificity from redirection of tropism to cancer-specific receptors, and are non-attenuated. To overcome the hurdles of systemic delivery, and enable oncolytic viruses (o-viruses) to reach metastatic sites, carrier cells are being exploited. Mesenchymal stromal cells (MSCs) were never tested as carriers of retargeted o-viruses, given their scarse-null expression of the cancer-specific receptors. We report that MSCs from diff ...[more]