Ontology highlight
ABSTRACT:
SUBMITTER: Parekh P
PROVIDER: S-EPMC3784013 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Parekh Parag P Kamble Sanchit S Zhao Nianxi N Zeng Zihua Z Portier Bryce P BP Zu Youli Y
Biomaterials 20130819 35
CD30 is highly expressed on Hodgkins lymphoma and anaplastic large cell lymphoma, making it an attractive target for therapy. We describe the generation of serum-stabilized ssDNA aptamers that bind CD30 via a hybrid SELEX methodology. The selected aptamer bound CD30 with high affinity and specificity. Further optimization of the aptamer led to a short, truncated variant with a 50-fold higher affinity than its longer counterpart. The multivalent aptamer was able to induce oligomerization of CD30 ...[more]