Evidence for novel genetic loci associated with metabolic traits in Yup'ik people.

ABSTRACT:

Objectives

To identify genomic regions associated with fasting plasma lipid profiles, insulin, glucose, and glycosylated hemoglobin in a Yup'ik study population, and to evaluate whether the observed associations between genetic factors and metabolic traits were modified by dietary intake of marine derived omega-3 polyunsaturated acids (n-3 PUFA).

Methods

A genome-wide linkage scan was conducted among 982 participants of the Center for Alaska Native Health Research study. n-3 PUFA intake was estimated using the nitrogen stable isotope ratio (δ(15) N) of erythrocytes. All genotyped SNPs located within genomic regions with LOD scores > 2 were subsequently tested for individual SNP associations with metabolic traits using linear models that account for familial correlation as we

SUBMITTER: Aslibekyan S 

PROVIDER: S-EPMC3785243 | biostudies-literature | 2013 Sep-Oct

REPOSITORIES: biostudies-literature