Novel genetic loci associated with hippocampal volume.
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ABSTRACT:
SUBMITTER: Hibar DP
PROVIDER: S-EPMC5253632 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Novel genetic loci associated with hippocampal volume.
Hibar Derrek P DP Adams Hieab H H HHH Jahanshad Neda N Chauhan Ganesh G Stein Jason L JL Hofer Edith E Renteria Miguel E ME Bis Joshua C JC Arias-Vasquez Alejandro A Ikram M Kamran MK Desrivières Sylvane S Vernooij Meike W MW Abramovic Lucija L Alhusaini Saud S Amin Najaf N Andersson Micael M Arfanakis Konstantinos K Aribisala Benjamin S BS Armstrong Nicola J NJ Athanasiu Lavinia L Axelsson Tomas T Beecham Ashley H AH Beiser Alexa A Bernard Manon M Blanton Susan H SH Bohlken Marc M MM Boks Marco P MP Bralten Janita J Brickman Adam M AM Carmichael Owen O Chakravarty M Mallar MM Chen Qiang Q Ching Christopher R K CRK Chouraki Vincent V Cuellar-Partida Gabriel G Crivello Fabrice F Den Braber Anouk A Doan Nhat Trung NT Ehrlich Stefan S Giddaluru Sudheer S Goldman Aaron L AL Gottesman Rebecca F RF Grimm Oliver O Griswold Michael E ME Guadalupe Tulio T Gutman Boris A BA Hass Johanna J Haukvik Unn K UK Hoehn David D Holmes Avram J AJ Hoogman Martine M Janowitz Deborah D Jia Tianye T Jørgensen Kjetil N KN Karbalai Nazanin N Kasperaviciute Dalia D Kim Sungeun S Klein Marieke M Kraemer Bernd B Lee Phil H PH Liewald David C M DCM Lopez Lorna M LM Luciano Michelle M Macare Christine C Marquand Andre F AF Matarin Mar M Mather Karen A KA Mattheisen Manuel M McKay David R DR Milaneschi Yuri Y Muñoz Maniega Susana S Nho Kwangsik K Nugent Allison C AC Nyquist Paul P Loohuis Loes M Olde LMO Oosterlaan Jaap J Papmeyer Martina M Pirpamer Lukas L Pütz Benno B Ramasamy Adaikalavan A Richards Jennifer S JS Risacher Shannon L SL Roiz-Santiañez Roberto R Rommelse Nanda N Ropele Stefan S Rose Emma J EJ Royle Natalie A NA Rundek Tatjana T Sämann Philipp G PG Saremi Arvin A Satizabal Claudia L CL Schmaal Lianne L Schork Andrew J AJ Shen Li L Shin Jean J Shumskaya Elena E Smith Albert V AV Sprooten Emma E Strike Lachlan T LT Teumer Alexander A Tordesillas-Gutierrez Diana D Toro Roberto R Trabzuni Daniah D Trompet Stella S Vaidya Dhananjay D Van der Grond Jeroen J Van der Lee Sven J SJ Van der Meer Dennis D Van Donkelaar Marjolein M J MMJ Van Eijk Kristel R KR Van Erp Theo G M TGM Van Rooij Daan D Walton Esther E Westlye Lars T LT Whelan Christopher D CD Windham Beverly G BG Winkler Anderson M AM Wittfeld Katharina K Woldehawariat Girma G Wolf Christiane C Wolfers Thomas T Yanek Lisa R LR Yang Jingyun J Zijdenbos Alex A Zwiers Marcel P MP Agartz Ingrid I Almasy Laura L Ames David D Amouyel Philippe P Andreassen Ole A OA Arepalli Sampath S Assareh Amelia A AA Barral Sandra S Bastin Mark E ME Becker Diane M DM Becker James T JT Bennett David A DA Blangero John J van Bokhoven Hans H Boomsma Dorret I DI Brodaty Henry H Brouwer Rachel M RM Brunner Han G HG Buckner Randy L RL Buitelaar Jan K JK Bulayeva Kazima B KB Cahn Wiepke W Calhoun Vince D VD Cannon Dara M DM Cavalleri Gianpiero L GL Cheng Ching-Yu CY Cichon Sven S Cookson Mark R MR Corvin Aiden A Crespo-Facorro Benedicto B Curran Joanne E JE Czisch Michael M Dale Anders M AM Davies Gareth E GE De Craen Anton J M AJM De Geus Eco J C EJC De Jager Philip L PL De Zubicaray Greig I GI Deary Ian J IJ Debette Stéphanie S DeCarli Charles C Delanty Norman N Depondt Chantal C DeStefano Anita A Dillman Allissa A Djurovic Srdjan S Donohoe Gary G Drevets Wayne C WC Duggirala Ravi R Dyer Thomas D TD Enzinger Christian C Erk Susanne S Espeseth Thomas T Fedko Iryna O IO Fernández Guillén G Ferrucci Luigi L Fisher Simon E SE Fleischman Debra A DA Ford Ian I Fornage Myriam M Foroud Tatiana M TM Fox Peter T PT Francks Clyde C Fukunaga Masaki M Gibbs J Raphael JR Glahn David C DC Gollub Randy L RL Göring Harald H H HHH Green Robert C RC Gruber Oliver O Gudnason Vilmundur V Guelfi Sebastian S Håberg Asta K AK Hansell Narelle K NK Hardy John J Hartman Catharina A CA Hashimoto Ryota R Hegenscheid Katrin K Heinz Andreas A Le Hellard Stephanie S Hernandez Dena G DG Heslenfeld Dirk J DJ Ho Beng-Choon BC Hoekstra Pieter J PJ Hoffmann Wolfgang W Hofman Albert A Holsboer Florian F Homuth Georg G Hosten Norbert N Hottenga Jouke-Jan JJ Huentelman Matthew M Hulshoff Pol Hilleke E HE Ikeda Masashi M Jack Clifford R CR Jenkinson Mark M Johnson Robert R Jönsson Erik G EG Jukema J Wouter JW Kahn René S RS Kanai Ryota R Kloszewska Iwona I Knopman David S DS Kochunov Peter P Kwok John B JB Lawrie Stephen M SM Lemaître Hervé H Liu Xinmin X Longo Dan L DL Lopez Oscar L OL Lovestone Simon S Martinez Oliver O Martinot Jean-Luc JL Mattay Venkata S VS McDonald Colm C McIntosh Andrew M AM McMahon Francis J FJ McMahon Katie L KL Mecocci Patrizia P Melle Ingrid I Meyer-Lindenberg Andreas A Mohnke Sebastian S Montgomery Grant W GW Morris Derek W DW Mosley Thomas H TH Mühleisen Thomas W TW Müller-Myhsok Bertram B Nalls Michael A MA Nauck Matthias M Nichols Thomas E TE Niessen Wiro J WJ Nöthen Markus M MM Nyberg Lars L Ohi Kazutaka K Olvera Rene L RL Ophoff Roel A RA Pandolfo Massimo M Paus Tomas T Pausova Zdenka Z Penninx Brenda W J H BWJH Pike G Bruce GB Potkin Steven G SG Psaty Bruce M BM Reppermund Simone S Rietschel Marcella M Roffman Joshua L JL Romanczuk-Seiferth Nina N Rotter Jerome I JI Ryten Mina M Sacco Ralph L RL Sachdev Perminder S PS Saykin Andrew J AJ Schmidt Reinhold R Schmidt Helena H Schofield Peter R PR Sigursson Sigurdur S Simmons Andrew A Singleton Andrew A Sisodiya Sanjay M SM Smith Colin C Smoller Jordan W JW Soininen Hilkka H Steen Vidar M VM Stott David J DJ Sussmann Jessika E JE Thalamuthu Anbupalam A Toga Arthur W AW Traynor Bryan J BJ Troncoso Juan J Tsolaki Magda M Tzourio Christophe C Uitterlinden Andre G AG Hernández Maria C Valdés MCV Van der Brug Marcel M van der Lugt Aad A van der Wee Nic J A NJA Van Haren Neeltje E M NEM van 't Ent Dennis D Van Tol Marie-Jose MJ Vardarajan Badri N BN Vellas Bruno B Veltman Dick J DJ Völzke Henry H Walter Henrik H Wardlaw Joanna M JM Wassink Thomas H TH Weale Michael E ME Weinberger Daniel R DR Weiner Michael W MW Wen Wei W Westman Eric E White Tonya T Wong Tien Y TY Wright Clinton B CB Zielke Ronald H RH Zonderman Alan B AB Martin Nicholas G NG Van Duijn Cornelia M CM Wright Margaret J MJ Longstreth W T WT Schumann Gunter G Grabe Hans J HJ Franke Barbara B Launer Lenore J LJ Medland Sarah E SE Seshadri Sudha S Thompson Paul M PM Ikram M Arfan MA
Nature communications 20170118
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. ...[more]