Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC3785767 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lee Ju-Hee JH Mahendran Adaickapillai A Yao Yuanshan Y Ngo Lang L Venta-Perez Gisela G Choy Megan L ML Kim Nathaniel N Ham Won-Seok WS Breslow Ronald R Marks Paul A PA
Proceedings of the National Academy of Sciences of the United States of America 20130910 39
Development of isoform-selective histone deacetylase (HDAC) inhibitors is important in elucidating the function of individual HDAC enzymes and their potential as therapeutic agents. Among the eleven zinc-dependent HDACs in humans, HDAC6 is structurally and functionally unique. Here, we show that a hydroxamic acid-based small-molecule N-hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide (HPOB) selectively inhibits HDAC6 catalytic activity in vivo and in vitro. HPOB causes growth in ...[more]