Ontology highlight
ABSTRACT:
SUBMITTER: Borretto E
PROVIDER: S-EPMC4027251 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Borretto Emily E Lazzarato Loretta L Spallotta Francesco F Cencioni Chiara C D'Alessandra Yuri Y Gaetano Carlo C Fruttero Roberta R Gasco Alberto A
ACS medicinal chemistry letters 20130904 10
The NO-donor histone deacetylase inhibitor 2, formally obtained by joining Entinostat 1, a moderately selective Class I histone deacetylases (HDACs) inhibitor, to a 4-(methylaminomethyl)furoxan-3-carbonitrile scaffold, is described and its preliminary biological profile discussed. This hybrid regulates Classes I and II HDACs. Nitric oxide (NO) released by the compound activates soluble guanylate cyclase (sGC), causing Class II nuclear shuttling and chromatin modifications, with consequences on g ...[more]