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Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures.

ABSTRACT: A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.

SUBMITTER: Hou S 

PROVIDER: S-EPMC3786692 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures.

Hou Shuang S   Zhao Haichao H   Zhao Libo L   Shen Qinglin Q   Wei Kevin S KS   Suh Daniel Y DY   Nakao Aiko A   Garcia Mitch A MA   Song Min M   Lee Tom T   Xiong Bin B   Luo Shyh-Chyang SC   Tseng Hsian-Rong HR   Yu Hsiao-hua HH  

Advanced materials (Deerfield Beach, Fla.) 20121217 11

A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability. ...[more]

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