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Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

ABSTRACT: A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.

SUBMITTER: Reategui E

PROVIDER: S-EPMC4492283 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Reátegui Eduardo E Aceto Nicola N Lim Eugene J EJ Sullivan James P JP Jensen Anne E AE Zeinali Mahnaz M Martel Joseph M JM Aranyosi Alexander J AJ Li Wei W Castleberry Steven S Bardia Aditya A Sequist Lecia V LV Haber Daniel A DA Maheswaran Shyamala S Hammond Paula T PT Toner Mehmet M Stott Shannon L SL

Advanced materials (Deerfield Beach, Fla.) 20150115 9

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. ...[more]

PMID: 25640006

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