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Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

ABSTRACT: A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

SUBMITTER: Yoon HJ 

PROVIDER: S-EPMC5680542 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Yoon Hyeun Joong HJ   Shanker Apoorv A   Wang Yang Y   Kozminsky Molly M   Jin Qu Q   Palanisamy Nallasivam N   Burness Monika L ML   Azizi Ebrahim E   Simeone Diane M DM   Wicha Max S MS   Kim Jinsang J   Nagrath Sunitha S  

Advanced materials (Deerfield Beach, Fla.) 20160426 24

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis. ...[more]

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