Ontology highlight
ABSTRACT:
SUBMITTER: Henault J
PROVIDER: S-EPMC3786711 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Henault Jill J Martinez Jennifer J Riggs Jeffrey M JM Tian Jane J Mehta Payal P Clarke Lorraine L Sasai Miwa M Latz Eicke E Brinkmann Melanie M MM Iwasaki Akiko A Coyle Anthony J AJ Kolbeck Roland R Green Douglas R DR Sanjuan Miguel A MA
Immunity 20121206 6
Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing immune complexes (DNA-IC), but not to soluble ligands, IFN-α production depended upon the convergence of the phagocytic and autophagic pathways, a process called microtubule-associ ...[more]