Ontology highlight
ABSTRACT:
SUBMITTER: Lindqvist LM
PROVIDER: S-EPMC5864185 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lindqvist Lisa M LM Frank Daniel D McArthur Kate K Dite Toby A TA Lazarou Michael M Oakhill Jonathan S JS Kile Benjamin T BT Vaux David L DL
Cell death and differentiation 20171211 4
Cells undergoing Bax/Bak-mediated apoptosis exhibit signs of autophagy, but how it is activated and its significance is unknown. By directly activating Bax/Bak with BH3-only proteins or BH3 mimetic compounds, we demonstrate that mitochondrial damage correlated with a rapid increase in intracellular [AMP]/[ATP], phosphorylation of 5' AMP-activated protein kinase (AMPK), and activation of unc-51 like autophagy activating kinase 1 (ULK1). Consequently, autophagic flux was triggered early in the apo ...[more]