Ontology highlight
ABSTRACT:
SUBMITTER: Inoue K
PROVIDER: S-EPMC3789823 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Inoue Keiichi K Rispoli Joanne J Yang Lichuan L Macleod David D Beal M Flint MF Klann Eric E Abeliovich Asa A
PLoS genetics 20131003 10
Macroautophagy is a conserved mechanism for the bulk degradation of proteins and organelles. Pathological studies have implicated defective macroautophagy in neurodegeneration, but physiological functions of macroautophagy in adult neurons remain unclear. Here we show that Atg7, an essential macroautophagy component, regulates dopaminergic axon terminal morphology. Mature Atg7-deficient midbrain dopamine (DA) neurons harbored selectively enlarged axonal terminals. This contrasted with the phenot ...[more]