Longitudinal decline of β-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study.

ABSTRACT:

Context

β-Cell function (BCF) declines over the course of type 2 diabetes, but little is known about BCF changes across glucose tolerance status (GTS) categories, and comparisons of direct vs surrogate measures.

Objective

To assess longitudinal changes in BCF across GTS.

Design

The Insulin Resistance Atherosclerosis Study is a multicenter, observational, epidemiologic study.

Setting

Four clinical centers in the US that could identify subjects likely to have impaired fasting glucose (IFG) or impaired glucose tolerance (IGT).

Patients

We compared longitudinal changes in BCF in 1052 subjects over 5 years. Subjects were categorized according to baseline GTS: normal glucose tolerance (NGT: n = 547), impaired fasting glucose or impaired glucose tolerance (IFG/

SUBMITTER: Festa A 

PROVIDER: S-EPMC3790620 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature