Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans.

ABSTRACT:

Purpose

Abnormal glucagon concentrations are a feature of prediabetes but it is uncertain if α-cell dysfunction contributes to a longitudinal decline in β-cell function. We therefore sought to determine if a decline in β-cell function is associated with a higher nadir glucagon in the postprandial period or with higher fasting glucagon.

Methods

This was a longitudinal study in which 73 non-diabetic subjects were studied on 2 occasions 6.6 ± 0.3 years apart using a 2-hour, 7-sample oral glucose tolerance test. Disposition Index (DI) was calculated using the oral minimal model applied to the measurements of glucose, insulin, C-peptide concentrations during the studies. We subsequently examined the relationship of glucagon concentrations at baseline with change in DI (used as a

SUBMITTER: Adams JD 

PROVIDER: S-EPMC7093233 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature