Ontology highlight
ABSTRACT:
SUBMITTER: Claypool SM
PROVIDER: S-EPMC379272 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Claypool Steven M SM Dickinson Bonny L BL Wagner Jessica S JS Johansen Finn-Eirik FE Venu Nanda N Borawski Jason A JA Lencer Wayne I WI Blumberg Richard S RS
Molecular biology of the cell 20040206 4
The human MHC class I-related neonatal Fc receptor, hFcRn, mediates bidirectional transport of IgG across mucosal barriers. Here, we find that at steady state hFcRn distributes predominantly to an apical intracellular compartment and almost exclusively to the basolateral cell surface of polarized epithelial cells. It moves only transiently to the apical membrane. Ligand binding does not redistribute the steady state location of the receptor. Removal of the cytoplasmic tail that contains di-leuci ...[more]