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Tissue-specific transcriptional regulation has diverged significantly between human and mouse.


ABSTRACT: We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.

SUBMITTER: Odom DT 

PROVIDER: S-EPMC3797512 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

Odom Duncan T DT   Dowell Robin D RD   Jacobsen Elizabeth S ES   Gordon William W   Danford Timothy W TW   MacIsaac Kenzie D KD   Rolfe P Alexander PA   Conboy Caitlin M CM   Gifford David K DK   Fraenkel Ernest E  

Nature genetics 20070521 6


We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximate  ...[more]

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