Ontology highlight
ABSTRACT:
SUBMITTER: Odom DT
PROVIDER: S-EPMC3797512 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Odom Duncan T DT Dowell Robin D RD Jacobsen Elizabeth S ES Gordon William W Danford Timothy W TW MacIsaac Kenzie D KD Rolfe P Alexander PA Conboy Caitlin M CM Gifford David K DK Fraenkel Ernest E
Nature genetics 20070521 6
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximate ...[more]