Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.
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ABSTRACT:
SUBMITTER: Ryder E
PROVIDER: S-EPMC3799019 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.
Ryder Edward E Wong Kim K Gleeson Diane D Keane Thomas M TM Sethi Debarati D Vyas Sapna S Wardle-Jones Hannah H Bussell James N JN Houghton Richard R Salisbury Jennifer J Harvey Nina N Adams David J DJ Ramirez-Solis Ramiro R
Genesis (New York, N.Y. : 2000) 20130525 7
We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. ...[more]
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