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Modular assembly of protein building blocks to create precisely defined megamolecules.

ABSTRACT: Enzyme-promoted assembly: The construction of a hetero-bifunctional protein building block, HaloTag-cutinase, that reacts rapidly and selectively with a small-molecule linker is described. The step-wise combination of these building blocks generates a 300 kDa "megamolecule" with precisely defined domain orientation, connectivity, and composition.

SUBMITTER: Modica JA 

PROVIDER: S-EPMC3804166 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Modular assembly of protein building blocks to create precisely defined megamolecules.

Modica Justin A JA   Skarpathiotis Stratos S   Mrksich Milan M  

Chembiochem : a European journal of chemical biology 20121015 16

Enzyme-promoted assembly: The construction of a hetero-bifunctional protein building block, HaloTag-cutinase, that reacts rapidly and selectively with a small-molecule linker is described. The step-wise combination of these building blocks generates a 300 kDa "megamolecule" with precisely defined domain orientation, connectivity, and composition. ...[more]

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