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Reverse orthogonal strategy for oligosaccharide synthesis.

ABSTRACT: Herein, we report the invention of a novel expeditious concept for oligosaccharide synthesis. Unlike the classic orthogonal strategy based on leaving groups, the reverse approach is based on orthogonal protecting groups, herein p-methoxybenzyl and 4-pentenoyl, which allows for efficient oligosaccharide assembly in the reverse direction.

SUBMITTER: Fujikawa K

PROVIDER: S-EPMC3805137 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Reverse orthogonal strategy for oligosaccharide synthesis.

Fujikawa Kohki K Ganesh N Vijaya NV Tan Yih Horng YH Stine Keith J KJ Demchenko Alexei V AV

Chemical communications (Cambridge, England) 20110905 38

Herein, we report the invention of a novel expeditious concept for oligosaccharide synthesis. Unlike the classic orthogonal strategy based on leaving groups, the reverse approach is based on orthogonal protecting groups, herein p-methoxybenzyl and 4-pentenoyl, which allows for efficient oligosaccharide assembly in the reverse direction. ...[more]

PMID: 21892457

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