Ontology highlight
ABSTRACT:
SUBMITTER: Jain N
PROVIDER: S-EPMC6208650 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
International journal of peptide research and therapeutics 20171101 4
We have developed a straightforward and robust strategy for synthesizing a family of cyclic peptide scaffolds for the presentation of defined moieties in a wide range of orientations. Specifically we are exploring quinoxaline as the moiety, as a potential nucleic acid binding motif. The method requires the use of four degrees of orthogonality, which in turn allow the extension of the main chain, incorporation of the target side chains, on-resin cyclization, and the revelation of an amino group u ...[more]