Ontology highlight
ABSTRACT:
SUBMITTER: San Pedro JM
PROVIDER: S-EPMC3807129 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20130812 13
Photolysis of an aryl sulfide-containing 5,6-dihydropyrimidine (1) at 350 nm produces high yields of thymidine and products resulting from trapping of a 5,6-dihydrothymidin-5-yl radical by O₂ or thiols. Thymidine is believed to result from disproportionation of the radical pair originally generated from C--S bond homolysis of 1 on the microsecond timescale, which is significantly shorter than other photochemical transformations of modified nucleotides into their native forms. Duplex DNA containi ...[more]