Ontology highlight
ABSTRACT:
SUBMITTER: Lusic H
PROVIDER: S-EPMC2532984 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Lusic Hrvoje H Young Douglas D DD Lively Mark O MO Deiters Alexander A
Organic letters 20070421 10
A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions. This approach enabled the disruption of specific H-bonds and allowed for the analysis of their contribution to the activity of a DNAzyme. Brief irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity. The developed strategy has the potential to find widespread application in the light-induced regulation of oligonucle ...[more]