Ontology highlight
ABSTRACT:
SUBMITTER: Dhaliwal B
PROVIDER: S-EPMC3807792 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Molecular immunology 20130807 4
IgE antibodies play a central role in allergic disease. They recognize allergens via their Fab regions, whilst their effector functions are controlled through interactions of the Fc region with two principal cell surface receptors, FcɛRI and CD23. Crosslinking of FcɛRI-bound IgE on mast cells and basophils by allergen initiates an immediate inflammatory response, while the interaction of IgE with CD23 on B-cells regulates IgE production. We have determined the structures of the C-type lectin "he ...[more]