Ontology highlight
ABSTRACT:
SUBMITTER: Dhaliwal B
PROVIDER: S-EPMC3944690 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20140220 Pt 3
The antibody IgE plays a central role in allergic disease, functioning principally through two cell-surface receptors: FcℇRI and CD23. FcℇRI on mast cells and basophils mediates the immediate hypersensitivity response, whilst the interaction of IgE with CD23 on B cells regulates IgE production. Crystal structures of the lectin-like `head' domain of CD23 alone and bound to a subfragment of IgE consisting of the dimer of Cℇ3 and Cℇ4 domains (Fcℇ3-4) have recently been determined, revealing flexibi ...[more]