Ontology highlight
ABSTRACT:
SUBMITTER: Dhaliwal B
PROVIDER: S-EPMC5374546 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170331
The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell surface receptors FcεRI and CD23. The interaction with FcεRI is primarily responsible for allergic sensitization and the inflammatory response, while IgE binding to CD23 is involved in the regulation of IgE synthesis and allergen transcytosis. Here we present the crystal structure of a CD23/IgE-Fc complex and conduct isother ...[more]