Ontology highlight
ABSTRACT:
SUBMITTER: Vaegter CB
PROVIDER: S-EPMC3808973 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature neuroscience 20101121 1
Binding of target-derived neurotrophins to Trk receptors at nerve terminals is required to stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance between the soma and nerve terminal is great, making efficient anterograde Trk transport critical for Trk synaptic translocation and signaling. The mechanism responsible for this trafficking remains poorly understood. Here we show that the sorting receptor sortilin interacts with TrkA, TrkB and TrkC and enables ...[more]