Dataset Information

IL-4 Receptor ? Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.

ABSTRACT: PURPOSE:The IL-4 and IL-4 receptor ? (IL-4R?) genes are the key candidate genes for atopy and asthma susceptibility. Exposure to wheat flour can cause IgE sensitization and respiratory symptoms in bakery workers. Therefore, we hypothesized that IL-4 and IL-4R? single nucleotide polymorphisms (SNPs) may be involved in the pathogenic mechanism of baker's asthma. METHODS:Clinical and genetic data from 373 bakery workers were analyzed. A survey questionnaire, spirometry, and skin prick tests with wheat flour were performed. Serum-specific IgE, IgG1, and IgG4 to wheat flour were determined using ELISA. Five candidate IL-4 (-729 T>G, 589 T>C, and 33 T>C) and IL-4R? (Ile75Val A>G and Gln576Arg A>G) SNPs were genotyped and analyzed. RESULTS:Workers with the G allele of IL-4R? Ile75Val A>G had a significantly higher prevalence of work-related lower respiratory symptoms than those with the AA genotype (P=0.004, 16.0% vs. 2.9%). In the skin prick test, workers with the AA genotype of IL-4R? Gln576Arg A>G had a significantly higher positive rate to wheat flour (P=0.015, 8.2% vs. 1.1%) than those with AG/GG genotype. No significant associations were found in the three genetic polymorphisms of IL-4. For the predicted probabilities, workers with the AA genotype of Gln576Arg A>G had a higher prevalence of IgG1 and IgG4 in response to wheat flour, according to increased exposure intensity (P=0.001 for IgG1 and P=0.003 for IgG4). CONCLUSIONS:These findings suggest that the IL-4R? Ile75Val and Gln576Arg polymorphisms may be associated with work-related respiratory symptom development.

SUBMITTER: Hur GY

PROVIDER: S-EPMC3810543 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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IL-4 Receptor α Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.

Hur Gyu-Young GY Ye Young-Min YM Koh Dong-Hee DH Kim Seung-Hyun SH Park Hae-Sim HS

Allergy, asthma & immunology research 20130702 6

<h4>Purpose</h4>The IL-4 and IL-4 receptor α (IL-4Rα) genes are the key candidate genes for atopy and asthma susceptibility. Exposure to wheat flour can cause IgE sensitization and respiratory symptoms in bakery workers. Therefore, we hypothesized that IL-4 and IL-4Rα single nucleotide polymorphisms (SNPs) may be involved in the pathogenic mechanism of baker's asthma.<h4>Methods</h4>Clinical and genetic data from 373 bakery workers were analyzed. A survey questionnaire, spirometry, and skin pric ...[more]

PMID: 24179683

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Project description:ObjectivesThe relationship between poverty and health has been well addressed in public health research. The health effects of social and economic inequalities on working groups have also drawn the attention of occupational health scholars. Research addressing workers in low-paying jobs showed increased risks for poor health. This research examined the psychosocial factors associated with poor mental health and self-rated health among low-income bakery workers performing demanding tasks.MethodsFace-to-face interviews in 504 randomly selected bakeries in Lebanon provided data on socio-demographics, perception of the workplace environment, job security, job satisfaction, general health, and mental health.ResultsIn total, 16.5% of bakery workers reported poor self-rated health, and 45% reported poor mental health. Workers with a chronic illness were almost three times more likely to report poor self-rated health (OR = 2.86; 95% CI = 1.44-5.67), and those with musculoskeletal pain reported poor self-rated health five times as often (OR = 5.34; 95% CI = 2.9-9.80). Those with a chronic illness and musculoskeletal pain were twice as likely to report poor mental health (OR = 1.94; 95% CI = 1.07-3.50 and OR = 2.07; 95% CI = 1.32-3.23, respectively); and those dissatisfied with their job reported poorer self-rated health (OR = 2.18; 95% CI = 1.12-4.23) and mental health (OR = 2.57; 95% CI = 1.54-4.26). In addition, workers reporting job insecurity had poor mental health twice as often (OR = 1.93; 95% CI = 1.24-2.99). Low socioeconomic indicators showed a gradient association with both poor self-rated health and mental health.ConclusionReporting job dissatisfaction and insecurity, musculoskeletal pain, and chronic illness were associated with poor mental and self-rated health among bakery workers. Interventions to improve the working conditions of bakery workers are timely and essential. This research provided evidence for policy to guide occupational health practice and safeguard the health of bakery workers.

Dataset Information

IL-4 Receptor ? Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.

Publications

IL-4 Receptor α Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.

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