Ontology highlight
ABSTRACT:
SUBMITTER: Dermenci A
PROVIDER: S-EPMC3811095 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Dermenci Alpay A Selig Philipp S PS Domaoal Robert A RA Spasov Krasimir A KA Anderson Karen S KS Miller Scott J SJ
Chemical science 20110801 8
Cysteine plays a number of important functional and structural roles in Nature, often in the realm of catalysis. Herein, we present an example of a cysteine-catalyzed Rauhut-Currier reaction for a potentially biomimetic synthesis of Sch-642305 and related analogs. In this key step of the synthesis we discuss interesting new discoveries and the importance of substrate-catalyst recognition, as well as cysteine's structural features. Also, we investigate the activity of Sch-642305 and four analogs ...[more]