Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
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ABSTRACT:
SUBMITTER: Lun S
PROVIDER: S-EPMC3811451 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Lun Shichun S Guo Haidan H Adamson John J Cisar Justin S JS Davis Tony D TD Chavadi Sivagami Sundaram SS Warren J David JD Warren J David JD Quadri Luis E N LE Tan Derek S DS Bishai William R WR
Antimicrobial agents and chemotherapy 20130715 10
Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose pharmacokinetic study and a monotherapy study of salicyl-AMS with mice. Intraperitoneal injection yielded much better pharmacokinetic parameter values than oral administration did. ...[more]
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