Ontology highlight
ABSTRACT:
SUBMITTER: Risinger AL
PROVIDER: S-EPMC5553283 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Risinger April L AL Li Jing J Du Lin L Benavides Raymond R Robles Andrew J AJ Cichewicz Robert H RH Kuhn John G JG Mooberry Susan L SL
Journal of natural products 20170123 2
The taccalonolides are microtubule stabilizers that covalently bind tubulin and circumvent clinically relevant forms of resistance to other drugs of this class. Efforts are under way to identify a taccalonolide with optimal properties for clinical development. The structurally similar taccalonolides AF and AJ have comparable microtubule-stabilizing activities in vitro, but taccalonolide AF has excellent in vivo antitumor efficacy when administered systemically, while taccalonolide AJ does not el ...[more]