Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes JC
PROVIDER: S-EPMC3817027 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
International journal of nanomedicine 20131031
Polyethylenimines (PEIs) are the most efficient synthetic vectors for gene delivery available to date. With its high charge density and strong proton-buffering effect, PEI has an ability to condense DNA and small interfering RNA at physiologic pH. However, the polymer suffers from the disadvantage of high cellular toxicity. To reduce its cellular toxicity, we synthesized linear PEIs by partial hydrolysis of poly(2-ethyl-2-oxazoline). Three linear PEIs with different hydrolysis percentages (30%, ...[more]