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Regioselective 1,4-trifluoromethylation of ?,?-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system.

ABSTRACT: Regioselective conjugate 1,4-trifluoromethylation of ?,?-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into ?-trifluoromethylated ketones in low to moderate yields.

SUBMITTER: Okusu S

PROVIDER: S-EPMC3817478 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system.

Okusu Satoshi S Sugita Yutaka Y Tokunaga Etsuko E Shibata Norio N

Beilstein journal of organic chemistry 20131023

Regioselective conjugate 1,4-trifluoromethylation of α,β-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into β-trifluoromethylated ketones in low to moderate yields. ...[more]

PMID: 24204432

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