Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni K
PROVIDER: S-EPMC3817697 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Biological crystallography 20131012 Pt 11
The anaphase-promoting complex (APC/C) is a large E3 ubiquitin ligase that regulates progression through specific stages of the cell cycle by coordinating the ubiquitin-dependent degradation of cell-cycle regulatory proteins. Depending on the species, the active form of the APC/C consists of 14-15 different proteins that assemble into a 20-subunit complex with a mass of approximately 1.3 MDa. A hybrid approach of single-particle electron microscopy and protein crystallography of individual APC/C ...[more]