Ontology highlight
ABSTRACT:
SUBMITTER: Koster S
PROVIDER: S-EPMC3818035 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Köster Stefan S Hudel Martina M Chakraborty Trinad T Yildiz Özkan Ö
Acta crystallographica. Section F, Structural biology and crystallization communications 20131017 Pt 11
The secreted pore-forming toxin listeriolysin O (LLO) from the intracellular pathogen Listeria monocytogenes is a member of the family of cholesterol-dependent cytolysins (CDC) with broad properties in pathogenesis. Its role as a virulence factor is enigmatic: it disrupts membranes and acts as an inductor of both pro- and anti-inflammatory responses in infected cells. In addition, LLO is also a potent target for immunogenicity during infection. Natively secreted LLO from a recombinant L. innocua ...[more]