Ontology highlight
ABSTRACT:
SUBMITTER: Di Paolo D
PROVIDER: S-EPMC4745691 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Di Paolo Daniela D Yang D D Pastorino Fabio F Emionite Laura L Cilli Michele M Daga Antonio A Destafanis Elisa E Di Fiore Annarita A Piaggio Francesca F Brignole Chiara C Xu Xiaobao X Liang Chris C Gibbons James J Ponzoni Mirco M Perri Patrizia P
Oncotarget 20151001 30
Many different aberrations in the Anaplastic Lymphoma Kinase (ALK) were found to be oncogenic drivers in several cancers including neuroblastoma (NB), therefore ALK is now considered a critical player in NB oncogenesis and a promising therapeutic target. The ALK-inhibitor crizotinib has a limited activity against the various ALK mutations identified in NB patients. We tested: the activity of the novel ALK-inhibitor X-396 administered alone or in combination with Targeted Liposomes carrying ALK-s ...[more]